Somatostatin receptor type 3 (SSTR3)

About Somatostatin receptor type 3

Somatostatin receptor type 3 (SSTR3) is a protein from Homo sapiens identified by UniProt accession P32745, 418 residues long. MolForge cross-references it against 0 known binders and 154 disease associations.

Target properties

Protein name	Somatostatin receptor type 3
UniProt accession	P32745
Gene	SSTR3
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (154)

Diseases linked to this target (Open Targets).

acromegaly · score 0.60
neoplasm · score 0.59
neuroendocrine neoplasm · score 0.58
carcinoid tumor · score 0.55
digestive system neuroendocrine neoplasm · score 0.54
carcinoid syndrome · score 0.52
obesity · score 0.51
cirrhosis of liver · score 0.50
esophageal varices · score 0.49
pituitary-dependent Cushing's disease · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32745-F1	alphafold	PREDICTED	74.59	—

Amino-acid sequence (418 residues)

MDMLHPSSVS TTSEPENASS AWPPDATLGN VSAGPSPAGL AVSGVLIPLV YLVVCVVGLL GNSLVIYVVL RHTASPSVTN VYILNLALAD ELFMLGLPFL AAQNALSYWP FGSLMCRLVM AVDGINQFTS IFCLTVMSVD RYLAVVHPTR SARWRTAPVA RTVSAAVWVA SAVVVLPVVV FSGVPRGMST CHMQWPEPAA AWRAGFIIYT AALGFFGPLL VICLCYLLIV VKVRSAGRRV WAPSCQRRRR SERRVTRMVV AVVALFVLCW MPFYVLNIVN VVCPLPEEPA FFGLYFLVVA LPYANSCANP ILYGFLSYRF KQGFRRVLLR PSRRVRSQEP TVGPPEKTEE EDEEEEDGEE SREGGKGKEM NGRVSQITQP GTSGQERPPS RVASKEQQLL PQEASTGEKS STMRISYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards