About Syntaxin-2
Syntaxin-2 (STX2) is a protein
from Homo sapiens identified by UniProt accession
P32856, 288 residues long.
MolForge cross-references it against 0 known binders and
276 disease associations.
Target properties
| Protein name | Syntaxin-2 |
|---|
| UniProt accession | P32856 |
|---|
| Gene | STX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (276)
Diseases linked to this target (Open Targets).
- von Willebrand factor measurement · score 0.38
- tissue plasminogen activator measurement · score 0.38
- cystatin C measurement · score 0.29
- azoospermia · score 0.09
- lean body mass · score 0.09
- hemolytic-uremic syndrome · score 0.09
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failures 50 · score 0.07
- spermatogenic failure 25 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32856-F1 | alphafold | PREDICTED | 83.16 | — |
Amino-acid sequence (288 residues)
MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK
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