About Corticotropin-releasing factor receptor 1
Corticotropin-releasing factor receptor 1 (CRHR1) is a protein
from Homo sapiens identified by UniProt accession
P34998, 415 residues long.
MolForge cross-references it against 0 known binders and
334 disease associations.
Target properties
| Protein name | Corticotropin-releasing factor receptor 1 |
|---|
| UniProt accession | P34998 |
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| Gene | CRHR1 |
|---|
| Organism | Homo sapiens |
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| Length | 415 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (334)
Diseases linked to this target (Open Targets).
- congenital adrenal hyperplasia · score 0.34
- neurodegenerative disease · score 0.31
- DNA methylation · score 0.30
- self reported educational attainment · score 0.28
- cognitive function measurement · score 0.28
- Parkinson disease · score 0.25
- mathematical ability · score 0.25
- Antithrombotic agent use measurement · score 0.25
- neuroticism measurement · score 0.24
- guilt measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34998-F1 | alphafold | PREDICTED | 77.32 | — |
Amino-acid sequence (415 residues)
MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS GLQCNASVDL IGTCWPRSPA GQLVVRPCPA FFYGVRYNTT NNGYRECLAN GSWAARVNYS ECQEILNEEK KSKVHYHVAV IINYLGHCIS LVALLVAFVL FLRLRSIRCL RNIIHWNLIS AFILRNATWF VVQLTMSPEV HQSNVGWCRL VTAAYNYFHV TNFFWMFGEG CYLHTAIVLT YSTDRLRKWM FICIGWGVPF PIIVAWAIGK LYYDNEKCWF GKRPGVYTDY IYQGPMILVL LINFIFLFNI VRILMTKLRA STTSETIQYR KAVKATLVLL PLLGITYMLF FVNPGEDEVS RVVFIYFNSF LESFQGFFVS VFYCFLNSEV RSAIRKRWHR WQDKHSIRAR VARAMSIPTS PTRVSFHSIK QSTAV
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