About Sepiapterin reductase
Sepiapterin reductase (SPR) is a protein
from Homo sapiens identified by UniProt accession
P35270, 261 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Sepiapterin reductase |
|---|
| UniProt accession | P35270 |
|---|
| Gene | SPR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- dopa-responsive dystonia due to sepiapterin reductase deficiency · score 0.83
- dopa-responsive dystonia · score 0.56
- Intellectual disability · score 0.55
- Dystonia · score 0.55
- dystonic disorder · score 0.54
- genetic disorder · score 0.40
- body height · score 0.33
- diastolic blood pressure · score 0.20
- hepatocellular carcinoma · score 0.08
- Young adult-onset Parkinsonism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35270-F1 | alphafold | PREDICTED | 96.71 | — |
Amino-acid sequence (261 residues)
MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF KSGAHVDFYD K
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