Small proline-rich protein 2B (SPRR2B)

About Small proline-rich protein 2B

Small proline-rich protein 2B (SPRR2B) is a protein from Homo sapiens identified by UniProt accession P35325, 72 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Small proline-rich protein 2B
UniProt accession	P35325
Gene	SPRR2B
Organism	Homo sapiens
Length	72 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
breast adenocarcinoma · score 0.22
gastric adenocarcinoma · score 0.17
neuroblastoma · score 0.13
psoriasis · score 0.11
endometrial cancer · score 0.10
atopic eczema · score 0.10
gonorrhea · score 0.05
neoplasm · score 0.04
monocyte count · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35325-F1	alphafold	PREDICTED	78.93	—

Amino-acid sequence (72 residues)

MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS PPCQPKYPPK SK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards