Small proline-rich protein 2A (SPRR2A)

About Small proline-rich protein 2A

Small proline-rich protein 2A (SPRR2A) is a protein from Homo sapiens identified by UniProt accession P35326, 72 residues long. MolForge cross-references it against 0 known binders and 210 disease associations.

Target properties

Protein name	Small proline-rich protein 2A
UniProt accession	P35326
Gene	SPRR2A
Organism	Homo sapiens
Length	72 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (210)

Diseases linked to this target (Open Targets).

clear cell renal carcinoma · score 0.18
ovarian cancer · score 0.18
neoplasm · score 0.10
gonorrhea · score 0.07
psoriasis · score 0.07
non-small cell lung carcinoma · score 0.05
actinic keratosis · score 0.05
sebaceous of Jadassohn nevus · score 0.05
esophageal squamous cell carcinoma · score 0.04
esophageal adenocarcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35326-F1	alphafold	PREDICTED	77.76	—

Amino-acid sequence (72 residues)

MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS PPCQSKYPPK SK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards