About Alpha-L-iduronidase
Alpha-L-iduronidase (IDUA) is a protein
from Homo sapiens identified by UniProt accession
P35475, 653 residues long.
MolForge cross-references it against 0 known binders and
435 disease associations.
Target properties
| Protein name | Alpha-L-iduronidase |
|---|
| UniProt accession | P35475 |
|---|
| Gene | IDUA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 653 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (435)
Diseases linked to this target (Open Targets).
- Scheie syndrome · score 0.85
- Hurler-Scheie syndrome · score 0.84
- Hurler syndrome · score 0.84
- mucopolysaccharidosis type 1 · score 0.74
- genetic disorder · score 0.51
- nephrolithiasis susceptibility caused by SLC26A1 · score 0.46
- calcium oxalate urolithiasis · score 0.46
- Interstitial pneumonitis · score 0.43
- heel bone mineral density · score 0.39
- bone density · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35475-F1 | alphafold | PREDICTED | 94.72 | — |
Amino-acid sequence (653 residues)
MRPLRPRAAL LALLASLLAA PPVAPAEAPH LVHVDAARAL WPLRRFWRST GFCPPLPHSQ ADQYVLSWDQ QLNLAYVGAV PHRGIKQVRT HWLLELVTTR GSTGRGLSYN FTHLDGYLDL LRENQLLPGF ELMGSASGHF TDFEDKQQVF EWKDLVSSLA RRYIGRYGLA HVSKWNFETW NEPDHHDFDN VSMTMQGFLN YYDACSEGLR AASPALRLGG PGDSFHTPPR SPLSWGLLRH CHDGTNFFTG EAGVRLDYIS LHRKGARSSI SILEQEKVVA QQIRQLFPKF ADTPIYNDEA DPLVGWSLPQ PWRADVTYAA MVVKVIAQHQ NLLLANTTSA FPYALLSNDN AFLSYHPHPF AQRTLTARFQ VNNTRPPHVQ LLRKPVLTAM GLLALLDEEQ LWAEVSQAGT VLDSNHTVGV LASAHRPQGP ADAWRAAVLI YASDDTRAHP NRSVAVTLRL RGVPPGPGLV YVTRYLDNGL CSPDGEWRRL GRPVFPTAEQ FRRMRAAEDP VAAAPRPLPA GGRLTLRPAL RLPSLLLVHV CARPEKPPGQ VTRLRALPLT QGQLVLVWSD EHVGSKCLWT YEIQFSQDGK AYTPVSRKPS TFNLFVFSPD TGAVSGSYRV RALDYWARPG PFSDPVPYLE VPVPRGPPSP GNP
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