About Metalloproteinase inhibitor 3
Metalloproteinase inhibitor 3 (TIMP3) is a protein
from Homo sapiens identified by UniProt accession
P35625, 211 residues long.
MolForge cross-references it against 0 known binders and
637 disease associations.
Target properties
| Protein name | Metalloproteinase inhibitor 3 |
|---|
| UniProt accession | P35625 |
|---|
| Gene | TIMP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (637)
Diseases linked to this target (Open Targets).
- Sorsby fundus dystrophy · score 0.75
- Sorsby's fundus dystrophy · score 0.67
- metalloproteinase inhibitor 3 measurement · score 0.39
- Retinal dystrophy · score 0.39
- blood protein measurement · score 0.30
- Cerebral arteriovenous malformation · score 0.27
- heel bone mineral density · score 0.25
- breast adenocarcinoma · score 0.25
- protein measurement · score 0.18
- acne · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35625-F1 | alphafold | PREDICTED | 87.00 | — |
Amino-acid sequence (211 residues)
MTPWLGLIVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYD GKMYTGLCNF VERWDQLTLS QRKGLNYRYH LGCNCKIKSC YYLPCFVTSK NECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP PDKSIINATD P
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