About Vasopressin V1a receptor
Vasopressin V1a receptor (AVPR1A) is a protein
from Homo sapiens identified by UniProt accession
P37288, 418 residues long.
MolForge cross-references it against 0 known binders and
281 disease associations.
Target properties
| Protein name | Vasopressin V1a receptor |
|---|
| UniProt accession | P37288 |
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| Gene | AVPR1A |
|---|
| Organism | Homo sapiens |
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| Length | 418 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (13)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (281)
Diseases linked to this target (Open Targets).
- hemorrhage · score 0.59
- enuresis · score 0.59
- diabetes insipidus · score 0.58
- Nasal congestion · score 0.56
- septic shock · score 0.56
- Central diabetes insipidus · score 0.55
- Abdominal distention · score 0.55
- Hyponatremia · score 0.55
- hepatorenal syndrome · score 0.53
- heart failure · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37288-F1 | alphafold | PREDICTED | 73.36 | — |
Amino-acid sequence (418 residues)
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFIPVST
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