Mozavaptan

Drug profile

Key facts

Mozavaptan is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2006. DrugCentral lists 7 molecular targets, including AVPR2, Avpr2 and AVPR1A. Recorded indications include Paraneoplastic hyponatremia.

• Molecular targets: AVPR2, Avpr2, AVPR1A and OXTR (7 listed in DrugCentral).
• Indications: Paraneoplastic hyponatremia.
• Molecular formula: C27H29N3O2; molecular weight 427.55 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Paraneoplastic hyponatremia

Mechanism & targets

Molecular targets (7)

Target	Gene	Action	Activity
Vasopressin V2 receptor	AVPR2	antagonist	Ki 8.03
Vasopressin V2 receptor	Avpr2	unknown	IC50 7.92
Vasopressin V1a receptor	AVPR1A	unknown	Ki 6.71
Oxytocin receptor	OXTR	unknown	Ki 6.18
Vasopressin V1a receptor	Avpr1a	unknown	IC50 5.85
Vasopressin V1 receptor	Avpr1a|Avpr1b	unknown	IC50 5.30
Vasopressin V1b receptor	AVPR1B	antagonist	Ki 4.80

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2006-07-26	PMDA	—	Otsuka Pharmaceutical Co., Ltd.

Chemical structure

• Molecular formula: C₂₇H₂₉N₃O₂
• Molecular weight: 427.55 g/mol
• CAS number: 137975-06-5
• InChIKey: WRNXUQJJCIZICJ-UHFFFAOYSA-N
• PubChem CID: 119369

CN(C)C1CCCN(C(=O)C2=CC=C(NC(=O)C3=C(C)C=CC=C3)C=C2)C2=CC=CC=C12

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Mozavaptan used for?

DrugCentral lists the following indications for Mozavaptan: Paraneoplastic hyponatremia.

How does Mozavaptan work?

Its molecular targets in DrugCentral include AVPR2 (antagonist), Avpr2, AVPR1A and OXTR.

When was Mozavaptan first approved?

Mozavaptan was first approved by the PMDA in 2006.

What is the chemical formula of Mozavaptan?

Mozavaptan has the molecular formula C27H29N3O2 and a molecular weight of 427.55 g/mol.

Sources

• DrugCentral drug card 4004 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL420762 — compound record and bioactivity
• PubChem CID 119369 — chemical identifiers
• FDA UNII 17OJ42922Y — substance identity
• UniProt P30518 (AVPR2) — target protein
• UniProt P37288 (AVPR1A) — target protein
• UniProt P30559 (OXTR) — target protein
• UniProt P47901 (AVPR1B) — target protein

How this page is built: methodology · editorial policy & corrections.