Vasopressin V2 receptor (AVPR2)

About Vasopressin V2 receptor

Vasopressin V2 receptor (AVPR2) is a protein from Homo sapiens identified by UniProt accession P30518, 371 residues long. MolForge cross-references it against 0 known binders and 290 disease associations.

Target properties

Protein name	Vasopressin V2 receptor
UniProt accession	P30518
Gene	AVPR2
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (290)

Diseases linked to this target (Open Targets).

nephrogenic syndrome of inappropriate antidiuresis · score 0.74
nephrogenic diabetes insipidus · score 0.72
hemorrhage · score 0.59
enuresis · score 0.59
Hyponatremia · score 0.59
diabetes insipidus · score 0.58
heart failure · score 0.58
Autosomal dominant polycystic kidney disease · score 0.57
Nasal congestion · score 0.56
septic shock · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30518-F1	alphafold	PREDICTED	76.02	—

Amino-acid sequence (371 residues)

MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA VALSNGLVLA ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ RNVEGGSGVT DCWACFAEPW GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP SERPGGRRRG RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT ASSSLAKDTS S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards