Vasopressin V1b receptor (AVPR1B)

About Vasopressin V1b receptor

Vasopressin V1b receptor (AVPR1B) is a protein from Homo sapiens identified by UniProt accession P47901, 424 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.

Target properties

Protein name	Vasopressin V1b receptor
UniProt accession	P47901
Gene	AVPR1B
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (147)

Diseases linked to this target (Open Targets).

hemorrhage · score 0.59
enuresis · score 0.59
diabetes insipidus · score 0.58
Nasal congestion · score 0.56
septic shock · score 0.56
Abdominal distention · score 0.55
Central diabetes insipidus · score 0.55
hepatorenal syndrome · score 0.53
head injury · score 0.53
hemophilia A · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47901-F1	alphafold	PREDICTED	73.67	—

Amino-acid sequence (424 residues)

MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE TIIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards