About Macrophage metalloelastase
Macrophage metalloelastase (MMP12) is a protein
from Homo sapiens identified by UniProt accession
P39900, 470 residues long.
MolForge cross-references it against 0 known binders and
442 disease associations.
Target properties
| Protein name | Macrophage metalloelastase |
|---|
| UniProt accession | P39900 |
|---|
| Gene | MMP12 |
|---|
| Organism | Homo sapiens |
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| Length | 470 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (442)
Diseases linked to this target (Open Targets).
- lung cancer · score 0.33
- blood protein measurement · score 0.33
- matrix metalloproteinase 12 measurement · score 0.30
- emphysema pattern measurement · score 0.29
- breast cancer · score 0.26
- macrophage metalloelastase measurement · score 0.25
- chronic obstructive pulmonary disease · score 0.25
- large artery stroke · score 0.23
- PHF-tau measurement · score 0.22
- matrix metalloproteinase measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P39900-F1 | alphafold | PREDICTED | 86.93 | — |
Amino-acid sequence (470 residues)
MKFLLILLLQ ATASGALPLN SSTSLEKNNV LFGERYLEKF YGLEINKLPV TKMKYSGNLM KEKIQEMQHF LGLKVTGQLD TSTLEMMHAP RCGVPDVHHF REMPGGPVWR KHYITYRINN YTPDMNREDV DYAIRKAFQV WSNVTPLKFS KINTGMADIL VVFARGAHGD FHAFDGKGGI LAHAFGPGSG IGGDAHFDED EFWTTHSGGT NLFLTAVHEI GHSLGLGHSS DPKAVMFPTY KYVDINTFRL SADDIRGIQS LYGDPKENQR LPNPDNSEPA LCDPNLSFDA VTTVGNKIFF FKDRFFWLKV SERPKTSVNL ISSLWPTLPS GIEAAYEIEA RNQVFLFKDD KYWLISNLRP EPNYPKSIHS FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY WRYDERRQMM DPGYPKLITK NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC
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