About Malate dehydrogenase, cytoplasmic
Malate dehydrogenase, cytoplasmic (MDH1) is a protein
from Homo sapiens identified by UniProt accession
P40925, 334 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | Malate dehydrogenase, cytoplasmic |
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| UniProt accession | P40925 |
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| Gene | MDH1 |
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| Organism | Homo sapiens |
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| Length | 334 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (107)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 88 · score 0.45
- neurodegenerative disease · score 0.34
- blood protein measurement · score 0.20
- sunburn · score 0.20
- prostate carcinoma · score 0.19
- attention deficit hyperactivity disorder · score 0.18
- asthma · score 0.18
- brain measurement · score 0.18
- neuroticism measurement · score 0.13
- hair color · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40925-F1 | alphafold | PREDICTED | 96.79 | — |
Amino-acid sequence (334 residues)
MSEPIRVLVT GAAGQIAYSL LYSIGNGSVF GKDQPIILVL LDITPMMGVL DGVLMELQDC ALPLLKDVIA TDKEDVAFKD LDVAILVGSM PRREGMERKD LLKANVKIFK SQGAALDKYA KKSVKVIVVG NPANTNCLTA SKSAPSIPKE NFSCLTRLDH NRAKAQIALK LGVTANDVKN VIIWGNHSST QYPDVNHAKV KLQGKEVGVY EALKDDSWLK GEFVTTVQQR GAAVIKARKL SSAMSAAKAI CDHVRDIWFG TPEGEFVSMG VISDGNSYGV PDDLLYSFPV VIKNKTWKFV EGLPINDFSR EKMDLTAKEL TEEKESAFEF LSSA
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