About Lamina-associated polypeptide 2, isoform alpha
Lamina-associated polypeptide 2, isoform alpha (TMPO) is a protein
from Homo sapiens identified by UniProt accession
P42166, 694 residues long.
MolForge cross-references it against 0 known binders and
159 disease associations.
Target properties
| Protein name | Lamina-associated polypeptide 2, isoform alpha |
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| UniProt accession | P42166 |
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| Gene | TMPO |
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| Organism | Homo sapiens |
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| Length | 694 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (159)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- familial isolated dilated cardiomyopathy · score 0.41
- neutrophil count · score 0.34
- drug use measurement · score 0.24
- neutrophil percentage of leukocytes · score 0.24
- waist-hip ratio · score 0.21
- metabolite measurement · score 0.20
- Loeys-Dietz syndrome · score 0.19
- neuropathic pain · score 0.19
- smoking status measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42166-F1 | alphafold | PREDICTED | 60.08 | — |
Amino-acid sequence (694 residues)
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS DRYSDNEEGK KKEHKKVKST RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA AKKVHTSKGD LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ SPLSSKRKAL EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM PPLDVENIQK RIDQSKFQET EFLSPPRKVP RLSEKSVEER DSGSFVAFQN IPGSELMSSF AKTVVSHSLT TLGLEVAKQS QHDKIDASEL SFPFHESILK VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI LGFISEATPL GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR RYLWLKDCKI NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH
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