About Signal transducer and activator of transcription 1-alpha/beta
Signal transducer and activator of transcription 1-alpha/beta (STAT1) is a protein
from Homo sapiens identified by UniProt accession
P42224, 750 residues long.
MolForge cross-references it against 0 known binders and
1,210 disease associations.
Target properties
| Protein name | Signal transducer and activator of transcription 1-alpha/beta |
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| UniProt accession | P42224 |
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| Gene | STAT1 |
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| Organism | Homo sapiens |
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| Length | 750 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1210)
Diseases linked to this target (Open Targets).
- Chronic mucocutaneous candidosis · score 0.82
- autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome · score 0.82
- Susceptibility to viral and mycobacterial infections · score 0.77
- immunodeficiency 31B · score 0.76
- cancer · score 0.55
- combined immunodeficiency · score 0.55
- Combined immunodeficiency · score 0.46
- hypothyroidism · score 0.46
- chronic mucocutaneous candidiasis · score 0.43
- developmental and epileptic encephalopathy · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42224-F1 | alphafold | PREDICTED | 87.23 | — |
Amino-acid sequence (750 residues)
MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ MSMIIYSCLK EERKILENAQ RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR EHETNGVAKS DQKQEQLLLK KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK RRQQSACIGG PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGTRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVAE PRNLSFFLTP PCARWAQLSE VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT RFCKENINDK NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG YIKTELISVS EVHPSRLQTT DNLLPMSPEE FDEVSRIVGS VEFDSMMNTV
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