About Excitatory amino acid transporter 1
Excitatory amino acid transporter 1 (SLC1A3) is a protein
from Homo sapiens identified by UniProt accession
P43003, 542 residues long.
MolForge cross-references it against 0 known binders and
334 disease associations.
Target properties
| Protein name | Excitatory amino acid transporter 1 |
|---|
| UniProt accession | P43003 |
|---|
| Gene | SLC1A3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 542 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (334)
Diseases linked to this target (Open Targets).
- episodic ataxia type 6 · score 0.72
- heel bone mineral density · score 0.51
- alkaline phosphatase measurement · score 0.50
- neurodegenerative disease · score 0.49
- Isaacs syndrome · score 0.46
- bone quantitative ultrasound measurement · score 0.42
- blood phosphate measurement · score 0.42
- FEV/FVC ratio · score 0.42
- hereditary episodic ataxia · score 0.41
- reticulocyte count · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43003-F1 | alphafold | PREDICTED | 82.01 | — |
Amino-acid sequence (542 residues)
MTKSNGEEPK MGGRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF VLLTVTAVIV GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMHREGK IVRVTAADAF LDLIRNMFPP NLVEACFKQF KTNYEKRSFK VPIQANETLV GAVINNVSEA METLTRITEE LVPVPGSVNG VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP VGILFLIAGK IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD GTALYEALAA IFIAQVNNFE LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN ETEKPIDSET KM
Explore Excitatory amino acid transporter 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets