About Excitatory amino acid transporter 2
Excitatory amino acid transporter 2 (SLC1A2) is a protein
from Homo sapiens identified by UniProt accession
P43004, 574 residues long.
MolForge cross-references it against 0 known binders and
293 disease associations.
Target properties
| Protein name | Excitatory amino acid transporter 2 |
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| UniProt accession | P43004 |
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| Gene | SLC1A2 |
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| Organism | Homo sapiens |
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| Length | 574 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (293)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 41 · score 0.75
- Epileptic encephalopathy · score 0.51
- early myoclonic encephalopathy · score 0.51
- developmental and epileptic encephalopathy · score 0.51
- type 2 diabetes mellitus · score 0.47
- neurodegenerative disease · score 0.45
- hypothyroidism · score 0.44
- FEV/FVC ratio · score 0.44
- Thyroid preparation use measurement · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43004-F1 | alphafold | PREDICTED | 77.76 | — |
Amino-acid sequence (574 residues)
MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK
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