Glucagon-like peptide 1 receptor (GLP1R)

About Glucagon-like peptide 1 receptor

Glucagon-like peptide 1 receptor (GLP1R) is a protein from Homo sapiens identified by UniProt accession P43220, 463 residues long. MolForge cross-references it against 0 known binders and 662 disease associations.

Target properties

Protein name	Glucagon-like peptide 1 receptor
UniProt accession	P43220
Gene	GLP1R
Organism	Homo sapiens
Length	463 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (662)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.75
diabetes mellitus · score 0.64
type 1 diabetes mellitus · score 0.61
obesity · score 0.60
polycystic ovary syndrome · score 0.55
prediabetes syndrome · score 0.54
non-alcoholic fatty liver disease · score 0.54
gestational diabetes · score 0.52
diabetic nephropathy · score 0.51
myocardial infarction · score 0.49

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43220-F1	alphafold	PREDICTED	81.51	—

Amino-acid sequence (463 residues)

MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL TEDPPPATDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLFLYIIYTV GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN YYWLLVEGVY LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ LEFRKSWERW RLEHLHIQRD SSMKPLKCPT SSLSSGATAG SSMYTATCQA SCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards