Translocon-associated protein subunit alpha (SSR1)

About Translocon-associated protein subunit alpha

Translocon-associated protein subunit alpha (SSR1) is a protein from Homo sapiens identified by UniProt accession P43307, 286 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.

Target properties

Protein name	Translocon-associated protein subunit alpha
UniProt accession	P43307
Gene	SSR1
Organism	Homo sapiens
Length	286 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (146)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.40
serum alanine aminotransferase measurement · score 0.34
neurodegenerative disease · score 0.33
heel bone mineral density · score 0.32
leukocyte count · score 0.30
Immature Reticulocyte Fraction Measurement · score 0.27
sitting height measurement · score 0.20
reticulocyte measurement · score 0.19
high density lipoprotein cholesterol measurement · score 0.18
sex hormone-binding globulin measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43307-F1	alphafold	PREDICTED	76.10	—

Amino-acid sequence (286 residues)

MRLLPRLLLL LLLVFPATVL FRGGPRGLLA VAQDLTEDEE TVEDSIIEDE DDEAEVEEDE PTDLVEDKEE EDVSGEPEAS PSADTTILFV KGEDFPANNI VKFLVGFTNK GTEDFIVESL DASFRYPQDY QFYIQNFTAL PLNTVVPPQR QATFEYSFIP AEPMGGRPFG LVINLNYKDL NGNVFQDAVF NQTVTVIERE DGLDGETIFM YMFLAGLGLL VIVGLHQLLE SRKRKRPIQK VEMGTSSQND VDMSWIPQET LNQINKASPR RLPRKRAQKR SVGSDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards