About Neuronal acetylcholine receptor subunit alpha-4
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) is a protein
from Homo sapiens identified by UniProt accession
P43681, 627 residues long.
MolForge cross-references it against 0 known binders and
473 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| UniProt accession | P43681 |
|---|
| Gene | CHRNA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 627 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (473)
Diseases linked to this target (Open Targets).
- nicotine dependence · score 0.72
- smoking cessation · score 0.70
- autosomal dominant nocturnal frontal lobe epilepsy · score 0.63
- schizophrenia · score 0.57
- dry eye syndrome · score 0.56
- alcohol dependence · score 0.55
- pain · score 0.54
- schizoaffective disorder · score 0.51
- major depressive disorder · score 0.50
- Parkinson disease · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43681-F1 | alphafold | PREDICTED | 71.95 | — |
Amino-acid sequence (627 residues)
MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK WSRPVANISD VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW DPADYENVTS IRIPSELIWR PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG SWTYDKAKID LVNMHSRVDQ LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR RLPLFYTINL IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD IVPRLLLMKR PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS LHPPSPSFCV PLDVPAEPGP SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR PPHGTQAPGL AKARSLSVQH MSSPGEAVEG GVRCRSRSIQ YCVPRDDAAP EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV SPSATVKTRS TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR IFLWMFIIVC LLGTVGLFLP PWLAGMI
Explore Neuronal acetylcholine receptor subunit alpha-4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets