Hexamethonium

Drug profile

Key facts

Hexamethonium is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including CHRNA1|CHRNB1|CHRNG|chrnd, CHRNA4 and Chrna4|Chrnb2.

• Molecular targets: CHRNA1|CHRNB1|CHRNG|chrnd, CHRNA4, Chrna4|Chrnb2 and CHRNB2|CHRNA4 (6 listed in DrugCentral).
• Molecular formula: C12H30N2; molecular weight 202.38 g/mol.

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Acetylcholine receptor	CHRNA1|CHRNB1|CHRNG|chrnd	unknown	Kd 5.74
Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	blocker	IC50 5.17
Neuronal acetylcholine receptor; alpha4/beta2	Chrna4|Chrnb2	unknown	Ki 4.66
Neuronal acetylcholine receptor; alpha4/beta2	CHRNB2|CHRNA4	unknown	IC50 4.54
Neuronal acetylcholine receptor; alpha4/beta4	CHRNB4|CHRNA4	unknown	IC50 4.04
Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	blocker	IC50 4.04

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Hexamethonium is on its molecule page.

• Molecular formula: C₁₂H₃₀N₂
• Molecular weight: 202.38 g/mol
• CAS number: 60-26-4
• InChIKey: VZJFGSRCJCXDSG-UHFFFAOYSA-N
• PubChem CID: 3604

C[N+](C)(C)CCCCCC[N+](C)(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Hexamethonium work?

Its molecular targets in DrugCentral include CHRNA1|CHRNB1|CHRNG|chrnd, CHRNA4 (blocker), Chrna4|Chrnb2 and CHRNB2|CHRNA4.

What is the chemical formula of Hexamethonium?

Hexamethonium has the molecular formula C12H30N2 and a molecular weight of 202.38 g/mol.

Sources

• DrugCentral drug card 1366 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL100622 — compound record and bioactivity
• PubChem CID 3604 — chemical identifiers
• DrugBank DB08960 — drug record
• FDA UNII 3C9PSP36Z2 — substance identity
• UniProt P43681 (CHRNA4) — target protein
• UniProt Q15825 (CHRNA6) — target protein

How this page is built: methodology · editorial policy & corrections.