About Neuronal acetylcholine receptor subunit alpha-6
Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6) is a protein
from Homo sapiens identified by UniProt accession
Q15825, 494 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-6 |
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| UniProt accession | Q15825 |
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| Gene | CHRNA6 |
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| Organism | Homo sapiens |
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| Length | 494 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (52)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.19
- eosinophil percentage of leukocytes · score 0.14
- smoking cessation · score 0.13
- attention deficit hyperactivity disorder · score 0.11
- smoking behavior · score 0.11
- Alzheimer disease · score 0.10
- Norrie disease · score 0.05
- colorectal adenocarcinoma · score 0.04
- nicotine dependence · score 0.04
- monocyte percentage of leukocytes · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15825-F1 | alphafold | PREDICTED | 79.47 | — |
Amino-acid sequence (494 residues)
MLTSKGQGFL HGGLCLWLCV FTPFFKGCVG CATEERLFHK LFSHYNQFIR PVENVSDPVT VHFEVAITQL ANVDEVNQIM ETNLWLRHIW NDYKLRWDPM EYDGIETLRV PADKIWKPDI VLYNNAVGDF QVEGKTKALL KYNGMITWTP PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF WENSEWEIID ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVV PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPTTHTMPRW VKTVFLKLLP QVLLMRWPLD KTRGTGSDAV PRGLARRPAK GKLASHGEPR HLKECFHCHK SNELATSKRR LSHQPLQWVV ENSEHSPEVE DVINSVQFIA ENMKSHNETK EVEDDWKYVA MVVDRVFLWV FIIVCVFGTA GLFLQPLLGN TGKS
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