About Troponin T, fast skeletal muscle
Troponin T, fast skeletal muscle (TNNT3) is a protein
from Homo sapiens identified by UniProt accession
P45378, 269 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Troponin T, fast skeletal muscle |
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| UniProt accession | P45378 |
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| Gene | TNNT3 |
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| Organism | Homo sapiens |
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| Length | 269 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (147)
Diseases linked to this target (Open Targets).
- distal arthrogryposis · score 0.65
- congenital myopathy · score 0.38
- Sheldon-hall syndrome · score 0.37
- digitotalar dysmorphism · score 0.37
- amyotrophic lateral sclerosis · score 0.34
- genetic disorder · score 0.33
- pulse pressure measurement · score 0.31
- systolic blood pressure · score 0.27
- diastolic blood pressure · score 0.26
- alcohol drinking · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45378-F1 | alphafold | PREDICTED | 77.23 | — |
Amino-acid sequence (269 residues)
MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEVQEDT AEEDAEEEKP RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAED DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL AERRKPLNID HLGEDKLRDK AKELWETLHQ LEIDKFEFGE KLKRQKYDIT TLRSRIDQAQ KHSKKAGTPA KGKVGGRWK
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