Troponin T, cardiac muscle (TNNT2)

About Troponin T, cardiac muscle

Troponin T, cardiac muscle (TNNT2) is a protein from Homo sapiens identified by UniProt accession P45379, 298 residues long. MolForge cross-references it against 0 known binders and 566 disease associations.

Target properties

Protein name	Troponin T, cardiac muscle
UniProt accession	P45379
Gene	TNNT2
Organism	Homo sapiens
Length	298 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (566)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy 2 · score 0.82
hypertrophic cardiomyopathy · score 0.76
cardiomyopathy, familial restrictive, 3 · score 0.74
dilated cardiomyopathy · score 0.69
left ventricular noncompaction · score 0.67
heart failure · score 0.58
Rare familial disorder with hypertrophic cardiomyopathy · score 0.57
cardiomyopathy · score 0.56
Abnormality of the cardiovascular system · score 0.56
familial hypertrophic cardiomyopathy · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P45379-F1	alphafold	PREDICTED	78.30	—

Amino-acid sequence (298 residues)

MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards