About Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) is a protein
from Homo sapiens identified by UniProt accession
P46977, 705 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A |
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| UniProt accession | P46977 |
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| Gene | STT3A |
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| Organism | Homo sapiens |
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| Length | 705 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation, type Iw, autosomal dominant · score 0.69
- STT3A-congenital disorder of glycosylation · score 0.69
- COVID-19 · score 0.37
- genetic disorder · score 0.19
- heel bone mineral density · score 0.17
- mean corpuscular hemoglobin concentration · score 0.15
- vital capacity · score 0.13
- Microcephaly · score 0.11
- mean corpuscular volume · score 0.11
- mean corpuscular hemoglobin · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46977-F1 | alphafold | PREDICTED | 88.34 | — |
Amino-acid sequence (705 residues)
MTKFGFLRLS YEKQDTLLKL LILSMAAVLS FSTRLFAVLR FESVIHEFDP YFNYRTTRFL AEEGFYKFHN WFDDRAWYPL GRIIGGTIYP GLMITSAAIY HVLHFFHITI DIRNVCVFLA PLFSSFTTIV TYHLTKELKD AGAGLLAAAM IAVVPGYISR SVAGSYDNEG IAIFCMLLTY YMWIKAVKTG SICWAAKCAL AYFYMVSSWG GYVFLINLIP LHVLVLMLTG RFSHRIYVAY CTVYCLGTIL SMQISFVGFQ PVLSSEHMAA FGVFGLCQIH AFVDYLRSKL NPQQFEVLFR SVISLVGFVL LTVGALLMLT GKISPWTGRF YSLLDPSYAK NNIPIIASVS EHQPTTWSSY YFDLQLLVFM FPVGLYYCFS NLSDARIFII MYGVTSMYFS AVMVRLMLVL APVMCILSGI GVSQVLSTYM KNLDISRPDK KSKKQQDSTY PIKNEVASGM ILVMAFFLIT YTFHSTWVTS EAYSSPSIVL SARGGDGSRI IFDDFREAYY WLRHNTPEDA KVMSWWDYGY QITAMANRTI LVDNNTWNNT HISRVGQAMA STEEKAYEIM RELDVSYVLV IFGGLTGYSS DDINKFLWMV RIGGSTDTGK HIKENDYYTP TGEFRVDREG SPVLLNCLMY KMCYYRFGQV YTEAKRPPGF DRVRNAEIGN KDFELDVLEE AYTTEHWLVR IYKVKDLDNR GLSRT
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