Glucagon receptor (GCGR)

About Glucagon receptor

Glucagon receptor (GCGR) is a protein from Homo sapiens identified by UniProt accession P47871, 477 residues long. MolForge cross-references it against 0 known binders and 230 disease associations.

Target properties

Protein name	Glucagon receptor
UniProt accession	P47871
Gene	GCGR
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (230)

Diseases linked to this target (Open Targets).

GCGR-related hyperglucagonemia · score 0.65
type 1 diabetes mellitus · score 0.58
diabetes mellitus · score 0.58
Hypoglycemia · score 0.56
infertility · score 0.37
congenital isolated hyperinsulinism · score 0.34
obesity · score 0.29
hemoglobin measurement · score 0.28
erythrocyte count · score 0.27
hematocrit · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47871-F1	alphafold	PREDICTED	81.90	—

Amino-acid sequence (477 residues)

MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL PPPTELVCNR TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC GPDGQWVRGP RGQPWRDASQ CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS LSLGALLLAL AILGGLSKLH CTRNAIHANL FASFVLKASS VLVIDGLLRT RYSQKIGDDL SVSTWLSDGA VAGCRVAAVF MQYGIVANYC WLLVEGLYLH NLLGLATLPE RSFFSLYLGI GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN MGFWWILRFP VFLAILINFF IFVRIVQLLV AKLRARQMHH TDYKFRLAKS TLTLIPLLGV HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS FQGLLVAVLY CFLNKEVQSE LRRRWHRWRL GKVLWEERNT SNHRASSSPG HGPPSKELQF GRGGGSQDSS AETPLAGGLP RLAESPF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards