About Inward rectifier potassium channel 4
Inward rectifier potassium channel 4 (KCNJ4) is a protein
from Homo sapiens identified by UniProt accession
P48050, 445 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Inward rectifier potassium channel 4 |
|---|
| UniProt accession | P48050 |
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| Gene | KCNJ4 |
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| Organism | Homo sapiens |
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| Length | 445 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (50)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.35
- self reported educational attainment · score 0.34
- neurodegenerative disease · score 0.28
- cognitive function measurement · score 0.25
- breast adenocarcinoma · score 0.22
- TPE interval measurement · score 0.21
- lung adenocarcinoma · score 0.19
- risk-taking behaviour · score 0.17
- chronotype measurement · score 0.13
- cutaneous melanoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48050-F1 | alphafold | PREDICTED | 78.81 | — |
Amino-acid sequence (445 residues)
MHGHSRNGQA HVPRRKRRNR FVKKNGQCNV YFANLSNKSQ RYMADIFTTC VDTRWRYMLM IFSAAFLVSW LFFGLLFWCI AFFHGDLEAS PGVPAAGGPA AGGGGAAPVA PKPCIMHVNG FLGAFLFSVE TQTTIGYGFR CVTEECPLAV IAVVVQSIVG CVIDSFMIGT IMAKMARPKK RAQTLLFSHH AVISVRDGKL CLMWRVGNLR KSHIVEAHVR AQLIKPYMTQ EGEYLPLDQR DLNVGYDIGL DRIFLVSPII IVHEIDEDSP LYGMGKEELE SEDFEIVVIL EGMVEATAMT TQARSSYLAS EILWGHRFEP VVFEEKSHYK VDYSRFHKTY EVAGTPCCSA RELQESKITV LPAPPPPPSA FCYENELALM SQEEEEMEEE AAAAAAVAAG LGLEAGSKEE AGIIRMLEFG SHLDLERMQA SLPLDNISYR RESAI
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