About Glycine receptor subunit beta
Glycine receptor subunit beta (GLRB) is a protein
from Homo sapiens identified by UniProt accession
P48167, 497 residues long.
MolForge cross-references it against 0 known binders and
250 disease associations.
Target properties
| Protein name | Glycine receptor subunit beta |
|---|
| UniProt accession | P48167 |
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| Gene | GLRB |
|---|
| Organism | Homo sapiens |
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| Length | 497 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (250)
Diseases linked to this target (Open Targets).
- hereditary hyperekplexia · score 0.74
- Seizure · score 0.27
- blood protein measurement · score 0.25
- PHF-tau measurement · score 0.24
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.18
- hyperekplexia · score 0.13
- lung adenocarcinoma · score 0.12
- squamous cell lung carcinoma · score 0.12
- esophageal cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48167-F1 | alphafold | PREDICTED | 78.05 | — |
Amino-acid sequence (497 residues)
MKFLLTTAFL ILISLWVEEA YSKEKSSKKG KGKKKQYLCP SQQSAEDLAR VPANSTSNIL NRLLVSYDPR IRPNFKGIPV DVVVNIFINS FGSIQETTMD YRVNIFLRQK WNDPRLKLPS DFRGSDALTV DPTMYKCLWK PDLFFANEKS ANFHDVTQEN ILLFIFRDGD VLVSMRLSIT LSCPLDLTLF PMDTQRCKMQ LESFGYTTDD LRFIWQSGDP VQLEKIALPQ FDIKKEDIEY GNCTKYYKGT GYYTCVEVIF TLRRQVGFYM MGVYAPTLLI VVLSWLSFWI NPDASAARVP LGIFSVLSLA SECTTLAAEL PKVSYVKALD VWLIACLLFG FASLVEYAVV QVMLNNPKRV EAEKARIAKA EQADGKGGNV AKKNTVNGTG TPVHISTLQV GETRCKKVCT SKSDLRSNDF SIVGSLPRDF ELSNYDCYGK PIEVNNGLGK SQAKNNKKPP PAKPVIPTAA KRIDLYARAL FPFCFLFFNV IYWSIYL
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