About Transmembrane 4 L6 family member 4
Transmembrane 4 L6 family member 4 (TM4SF4) is a protein
from Homo sapiens identified by UniProt accession
P48230, 202 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Transmembrane 4 L6 family member 4 |
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| UniProt accession | P48230 |
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| Gene | TM4SF4 |
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| Organism | Homo sapiens |
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| Length | 202 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.47
- cholelithiasis · score 0.47
- serum gamma-glutamyl transferase measurement · score 0.46
- gallstones · score 0.43
- gallbladder disease · score 0.41
- urate measurement · score 0.41
- uric acid measurement · score 0.41
- alkaline phosphatase measurement · score 0.37
- type 2 diabetes mellitus · score 0.36
- biliary tract disease · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48230-F1 | alphafold | PREDICTED | 76.70 | — |
Amino-acid sequence (202 residues)
MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG GILGSGVLMI FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF LGAGYSFIIS AISINKGPKC LMANSTWGYP FHDGDYLNDE ALWNKCREPL NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN GLLGTLCGDC QCCGCCGGDG PV
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