About Casein kinase I isoform alpha
Casein kinase I isoform alpha (CSNK1A1) is a protein
from Homo sapiens identified by UniProt accession
P48729, 337 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Casein kinase I isoform alpha |
|---|
| UniProt accession | P48729 |
|---|
| Gene | CSNK1A1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 337 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (134)
Diseases linked to this target (Open Targets).
- cancer · score 0.55
- neurodegenerative disease · score 0.52
- Alzheimer disease · score 0.50
- multiple sclerosis · score 0.50
- Parkinson disease · score 0.50
- lysosomal storage disease · score 0.50
- neuroinflammatory disorder · score 0.37
- COVID-19 · score 0.37
- chronic myelogenous leukemia · score 0.37
- endometrial cancer · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48729-F1 | alphafold | PREDICTED | 91.40 | — |
Amino-acid sequence (337 residues)
MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM LKQKAAQQAA SSSGQGQQAQ TPTGKQTDKT KSNMKGF
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