About Neuropeptide Y receptor type 2
Neuropeptide Y receptor type 2 (NPY2R) is a protein
from Homo sapiens identified by UniProt accession
P49146, 381 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Neuropeptide Y receptor type 2 |
|---|
| UniProt accession | P49146 |
|---|
| Gene | NPY2R |
|---|
| Organism | Homo sapiens |
|---|
| Length | 381 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (156)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.26
- breast adenocarcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.16
- prostate adenocarcinoma · score 0.10
- bulimia nervosa · score 0.09
- obesity · score 0.08
- anxiety · score 0.06
- glycoprotein storage disease · score 0.05
- obesity due to melanocortin 4 receptor deficiency · score 0.05
- ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49146-F1 | alphafold | PREDICTED | 82.50 | — |
Amino-acid sequence (381 residues)
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V
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