About Glutamate dehydrogenase 2, mitochondrial
Glutamate dehydrogenase 2, mitochondrial (GLUD2) is a protein
from Homo sapiens identified by UniProt accession
P49448, 558 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Glutamate dehydrogenase 2, mitochondrial |
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| UniProt accession | P49448 |
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| Gene | GLUD2 |
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| Organism | Homo sapiens |
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| Length | 558 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.27
- Parkinson disease · score 0.15
- Hereditary late-onset Parkinson disease · score 0.15
- skin disease · score 0.09
- cancer · score 0.01
- Hyperammonemia · score 0.01
- Rheumatoid arthritis · score 0.01
- infection · score 0.01
- Autism · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49448-F1 | alphafold | PREDICTED | 90.20 | — |
Amino-acid sequence (558 residues)
MYRYLAKALL PSRAGPAALG SAANHSAALL GRGRGQPAAA SQPGLALAAR RHYSELVADR EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLLSV QESLERKFGK HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV NAIEKVFKVY SEAGVTFT
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