About Steroidogenic acute regulatory protein, mitochondrial
Steroidogenic acute regulatory protein, mitochondrial (STAR) is a protein
from Homo sapiens identified by UniProt accession
P49675, 285 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Steroidogenic acute regulatory protein, mitochondrial |
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| UniProt accession | P49675 |
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| Gene | STAR |
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| Organism | Homo sapiens |
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| Length | 285 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (208)
Diseases linked to this target (Open Targets).
- congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.81
- syndactyly-telecanthus-anogenital and renal malformations syndrome · score 0.43
- Syndactyly - telecanthus - anogenital and renal malformations · score 0.43
- non-classic congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.37
- classic congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.37
- alternating hemiplegia of childhood · score 0.37
- X-linked adrenal hypoplasia congenita · score 0.37
- ovarian cancer · score 0.18
- genetic disorder · score 0.18
- congenital adrenal hyperplasia · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49675-F1 | alphafold | PREDICTED | 82.57 | — |
Amino-acid sequence (285 residues)
MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN QVRRRSSLLG SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES QQDNGDKVMS KVVPDVGKVF RLEVVVDQPM ERLYEELVER MEAMGEWNPN VKEIKVLQKI GKDTFITHEL AAEAAGNLVG PRDFVSVRCA KRRGSTCVLA GMATDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT WLLSIDLKGW LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC
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