About Transmembrane emp24 domain-containing protein 10
Transmembrane emp24 domain-containing protein 10 (TMED10) is a protein
from Homo sapiens identified by UniProt accession
P49755, 219 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Transmembrane emp24 domain-containing protein 10 |
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| UniProt accession | P49755 |
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| Gene | TMED10 |
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| Organism | Homo sapiens |
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| Length | 219 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (60)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- lysosomal storage disease · score 0.37
- lung adenocarcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- heel bone mineral density · score 0.07
- inflammatory bowel disease · score 0.06
- Epidermal Inclusion Cyst · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.05
- Testicular regression syndrome · score 0.05
- isolated congenital hypogonadotropic hypogonadism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49755-F1 | alphafold | PREDICTED | 87.45 | — |
Amino-acid sequence (219 residues)
MSGLSGPPAR RGPFPLALLL LFLLGPRLVL AISFHLPINS RKCLREEIHK DLLVTGAYEI SDQSGGAGGL RSHLKITDSA GHILYSKEDA TKGKFAFTTE DYDMFEVCFE SKGTGRIPDQ LVILDMKHGV EAKNYEEIAK VEKLKPLEVE LRRLEDLSES IVNDFAYMKK REEEMRDTNE STNTRVLYFS IFSMFCLIGL ATWQVFYLRR FFKAKKLIE
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