About Tumor necrosis factor ligand superfamily member 10
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) is a protein
from Homo sapiens identified by UniProt accession
P50591, 281 residues long.
MolForge cross-references it against 0 known binders and
895 disease associations.
Target properties
| Protein name | Tumor necrosis factor ligand superfamily member 10 |
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| UniProt accession | P50591 |
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| Gene | TNFSF10 |
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| Organism | Homo sapiens |
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| Length | 281 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (895)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.48
- serum alanine aminotransferase measurement · score 0.48
- aspartate aminotransferase measurement · score 0.47
- TNF-related apoptosis-inducing ligand measurement · score 0.45
- platelet count · score 0.42
- triglyceride measurement · score 0.41
- monocyte count · score 0.41
- monocyte percentage of leukocytes · score 0.41
- serum gamma-glutamyl transferase measurement · score 0.39
- TNF-related activation-induced cytokine measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50591-F1 | alphafold | PREDICTED | 81.70 | — |
Amino-acid sequence (281 residues)
MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS KSGIACFLKE DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI STVQEKQQNI SPLVRERGPQ RVAAHITGTR GRSNTLSSPN SKNEKALGRK INSWESSRSG HSFLSNLHLR NGELVIHEKG FYYIYSQTYF RFQEEIKENT KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY SIYQGGIFEL KENDRIFVSV TNEHLIDMDH EASFFGAFLV G
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