About Signal transducer and activator of transcription 5B
Signal transducer and activator of transcription 5B (STAT5B) is a protein
from Homo sapiens identified by UniProt accession
P51692, 787 residues long.
MolForge cross-references it against 0 known binders and
503 disease associations.
Target properties
| Protein name | Signal transducer and activator of transcription 5B |
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| UniProt accession | P51692 |
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| Gene | STAT5B |
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| Organism | Homo sapiens |
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| Length | 787 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (503)
Diseases linked to this target (Open Targets).
- growth hormone insensitivity with immune dysregulation 1, autosomal recessive · score 0.78
- growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant · score 0.68
- cancer · score 0.60
- Combined immunodeficiency · score 0.46
- combined immunodeficiency · score 0.46
- T-B+ severe combined immunodeficiency · score 0.46
- acute myeloid leukemia · score 0.45
- skin basal cell carcinoma · score 0.38
- Merkel cell skin cancer · score 0.37
- lymphoid neoplasm · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51692-F1 | alphafold | PREDICTED | 85.18 | — |
Amino-acid sequence (787 residues)
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGG GSATYMDQAP SPAVCPQAHY NMYPQNPDSV LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ WIPHAQS
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