About Lumican
Lumican (LUM) is a protein
from Homo sapiens identified by UniProt accession
P51884, 338 residues long.
MolForge cross-references it against 0 known binders and
374 disease associations.
Target properties
| Protein name | Lumican |
|---|
| UniProt accession | P51884 |
|---|
| Gene | LUM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 338 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (374)
Diseases linked to this target (Open Targets).
- body height · score 0.40
- fat body mass · score 0.38
- body fat percentage · score 0.36
- fibroblastic disorder · score 0.32
- chronic obstructive pulmonary disease · score 0.29
- central corneal thickness · score 0.29
- cutaneous melanoma · score 0.26
- lung adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.24
- intraocular pressure measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51884-F1 | alphafold | PREDICTED | 90.37 | — |
Amino-acid sequence (338 residues)
MSLSAFTLFL ALIGGTSGQY YDYDFPLSIY GQSSPNCAPE CNCPESYPSA MYCDELKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGR VFSKLKQLKK LHINHNNLTE SVGPLPKSLE DLQLTHNKIT KLGSFEGLVN LTFIHLQHNR LKEDAVSAAF KGLKSLEYLD LSFNQIARLP SGLPVSLLTL YLDNNKISNI PDEYFKRFNA LQYLRLSHNE LADSGIPGNS FNVSSLVELD LSYNKLKNIP TVNENLENYY LEVNQLEKFD IKSFCKILGP LSYSKIKHLR LDGNRISETS LPPDMYECLR VANEVTLN
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