About Serine/threonine-protein kinase Nek2
Serine/threonine-protein kinase Nek2 (NEK2) is a protein
from Homo sapiens identified by UniProt accession
P51955, 445 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Nek2 |
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| UniProt accession | P51955 |
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| Gene | NEK2 |
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| Organism | Homo sapiens |
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| Length | 445 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (176)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.47
- Red cell distribution width · score 0.46
- Retinal dystrophy · score 0.40
- mean corpuscular hemoglobin concentration · score 0.37
- mean corpuscular hemoglobin · score 0.33
- alkaline phosphatase measurement · score 0.32
- platelet component distribution width · score 0.30
- neurodegenerative disease · score 0.29
- mean reticulocyte volume · score 0.26
- breast adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51955-F1 | alphafold | PREDICTED | 78.05 | — |
Amino-acid sequence (445 residues)
MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA QLRAQALSDI EKNYQLKSRQ ILGMR
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