About Serine/threonine-protein kinase Nek3
Serine/threonine-protein kinase Nek3 (NEK3) is a protein
from Homo sapiens identified by UniProt accession
P51956, 506 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Nek3 |
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| UniProt accession | P51956 |
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| Gene | NEK3 |
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| Organism | Homo sapiens |
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| Length | 506 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- hereditary breast ovarian cancer syndrome · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
- anti-chlamydia trachomatis antibody measurement · score 0.05
- Red cell distribution width · score 0.04
- esophageal adenocarcinoma · score 0.04
- cancer · score 0.03
- lymph node metastatic carcinoma · score 0.02
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.01
- breast cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51956-F1 | alphafold | PREDICTED | 65.09 | — |
Amino-acid sequence (506 residues)
MDDYMVLRMI GEGSFGRALL VQHESSNQMF AMKEIRLPKS FSNTQNSRKE AVLLAKMKHP NIVAFKESFE AEGHLYIVME YCDGGDLMQK IKQQKGKLFP EDMILNWFTQ MCLGVNHIHK KRVLHRDIKS KNIFLTQNGK VKLGDFGSAR LLSNPMAFAC TYVGTPYYVP PEIWENLPYN NKSDIWSLGC ILYELCTLKH PFQANSWKNL ILKVCQGCIS PLPSHYSYEL QFLVKQMFKR NPSHRPSATT LLSRGIVARL VQKCLPPEII MEYGEEVLEE IKNSKHNTPR KKTNPSRIRI ALGNEASTVQ EEEQDRKGSH TDLESINENL VESALRRVNR EEKGNKSVHL RKASSPNLHR RQWEKNVPNT ALTALENASI LTSSLTAEDD RGGSVIKYSK NTTRKQWLKE TPDTLLNILK NADLSLAFQT YTIYRPGSEG FLKGPLSEET EASDSVDGGH DSVILDPERL EPGLDEEDTD FEEEDDNPDW VSELKKRAGW QGLCDR
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