About Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (SUCLG1) is a protein
from Homo sapiens identified by UniProt accession
P53597, 346 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
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| UniProt accession | P53597 |
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| Gene | SUCLG1 |
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| Organism | Homo sapiens |
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| Length | 346 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (118)
Diseases linked to this target (Open Targets).
- mitochondrial DNA depletion syndrome 9 · score 0.78
- Fatal infantile lactic acidosis with methylmalonic aciduria · score 0.75
- mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria · score 0.56
- mitochondrial DNA depletion syndrome · score 0.55
- neurodegenerative disease · score 0.52
- lysosomal storage disease · score 0.25
- genetic disorder · score 0.19
- Leigh syndrome · score 0.19
- intraocular pressure measurement · score 0.17
- PHF-tau measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53597-F1 | alphafold | PREDICTED | 91.42 | — |
Amino-acid sequence (346 residues)
MTATLAAAAD IATMVSGSSG LAAARLLSRS FLLPQNGIRH CSYTASRQHL YVDKNTKIIC QGFTGKQGTF HSQQALEYGT KLVGGTTPGK GGQTHLGLPV FNTVKEAKEQ TGATASVIYV PPPFAAAAIN EAIEAEIPLV VCITEGIPQQ DMVRVKHKLL RQEKTRLIGP NCPGVINPGE CKIGIMPGHI HKKGRIGIVS RSGTLTYEAV HQTTQVGLGQ SLCVGIGGDP FNGTDFIDCL EIFLNDSATE GIILIGEIGG NAEENAAEFL KQHNSGPNSK PVVSFIAGLT APPGRRMGHA GAIIAGGKGG AKEKISALQS AGVVVSMSPA QLGTTIYKEF EKRKML
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