Dipeptidyl peptidase 1 (CTSC)

About Dipeptidyl peptidase 1

Dipeptidyl peptidase 1 (CTSC) is a protein from Homo sapiens identified by UniProt accession P53634, 463 residues long. MolForge cross-references it against 0 known binders and 260 disease associations.

Target properties

Protein name	Dipeptidyl peptidase 1
UniProt accession	P53634
Gene	CTSC
Organism	Homo sapiens
Length	463 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (260)

Diseases linked to this target (Open Targets).

Papillon-Lefèvre syndrome · score 0.83
Haim-Munk syndrome · score 0.80
aggressive periodontitis · score 0.78
Papillon-Lefevre disease · score 0.77
periodontitis · score 0.73
chronic periodontitis · score 0.73
blood protein measurement · score 0.49
monocyte count · score 0.47
Palmoplantar keratoderma · score 0.46
CTSC-related disorder · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53634-F1	alphafold	PREDICTED	90.13	—

Amino-acid sequence (463 residues)

MGAGPSLLLA ALLLLLSGDG AVRCDTPANC TYLDLLGTWV FQVGSSGSQR DVNCSVMGPQ EKKVVVYLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK WFAFFKYKEE GSKVTTYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY VNIAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY MEYETLTLGD MIRRSGGHSR KIPRPKPAPL TAEIQQKILH LPTSWDWRNV HGINFVSPVR NQASCGSCYS FASMGMLEAR IRILTNNSQT PILSPQEVVS CSQYAQGCEG GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG FYGGCNEALM KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TGWGENGYFR IRRGTDECAI ESIAVAATPI PKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards