Brensocatib

Drug profile

Key facts

Brensocatib is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2025. DrugCentral lists 3 molecular targets, including CTSC, Ctsc and Ctsc. Recorded indications include Non-cystic fibrosis bronchiectasis.

• Approval status: onp (first approved 2025 by the FDA).
• Molecular targets: CTSC, Ctsc and Ctsc (3 listed in DrugCentral).
• Indications: Non-cystic fibrosis bronchiectasis.
• Molecular formula: C23H24N4O4; molecular weight 420.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Non-cystic fibrosis bronchiectasis

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Dipeptidyl peptidase 1	CTSC	inhibitor	IC50 8.40
Dipeptidyl peptidase 1	Ctsc	inhibitor	IC50 7.70
Dipeptidyl peptidase 1	Ctsc	inhibitor	IC50 7.60

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2025-11-18	EMA	—	Insmed Netherlands B.V.
2025-08-12	FDA	—	Insmed Inc.

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Brensocatib is on its molecule page.

• Molecular formula: C₂₃H₂₄N₄O₄
• Molecular weight: 420.47 g/mol
• CAS number: —
• InChIKey: AEXFXNFMSAAELR-RXVVDRJESA-N
• PubChem CID: 118253852

CN1C2=C(C=CC(=C2)C3=CC=C(C=C3)C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)OC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Brensocatib used for?

DrugCentral lists the following indications for Brensocatib: Non-cystic fibrosis bronchiectasis.

How does Brensocatib work?

Its molecular targets in DrugCentral include CTSC (inhibitor), Ctsc (inhibitor) and Ctsc (inhibitor).

When was Brensocatib first approved?

Brensocatib was first approved by the FDA in 2025.

What is the chemical formula of Brensocatib?

Brensocatib has the molecular formula C23H24N4O4 and a molecular weight of 420.47 g/mol.

Sources

• DrugCentral drug card 5791 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3900409 — compound record and bioactivity
• PubChem CID 118253852 — chemical identifiers
• DrugBank DB15638 — drug record
• FDA UNII 25CG88L0BB — substance identity
• DailyMed: FDA labels for Brensocatib — current prescribing information (label search)
• UniProt P53634 (CTSC) — target protein

How this page is built: methodology · editorial policy & corrections.