IST1 homolog (IST1)

About IST1 homolog

IST1 homolog (IST1) is a protein from Homo sapiens identified by UniProt accession P53990, 364 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	IST1 homolog
UniProt accession	P53990
Gene	IST1
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
reticulocyte count · score 0.23
reticulocyte measurement · score 0.22
self reported educational attainment · score 0.20
intelligence · score 0.16
cognitive function measurement · score 0.15
high density lipoprotein cholesterol measurement · score 0.15
creatinine measurement · score 0.15
hair colour measurement · score 0.13
red blood cell density measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53990-F1	alphafold	PREDICTED	72.25	—

Amino-acid sequence (364 residues)

MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL KKKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards