Activated RNA polymerase II transcriptional…

About Activated RNA polymerase II transcriptional coactivator p15

Activated RNA polymerase II transcriptional coactivator p15 (SUB1) is a protein from Homo sapiens identified by UniProt accession P53999, 127 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Activated RNA polymerase II transcriptional coactivator p15
UniProt accession	P53999
Gene	SUB1
Organism	Homo sapiens
Length	127 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

breast carcinoma · score 0.42
PR interval · score 0.27
neurodegenerative disease · score 0.19
hepatocellular carcinoma · score 0.19
bladder transitional cell carcinoma · score 0.19
non-small cell lung carcinoma · score 0.19
urinary bladder carcinoma · score 0.19
pancreatic ductal adenocarcinoma · score 0.19
pancreatic carcinoma · score 0.19
acute myeloid leukemia · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53999-F1	alphafold	PREDICTED	75.93	—

Amino-acid sequence (127 residues)

MPKSKELVSS SSSGSDSDSE VDKKLKRKKQ VAPEKPVKKQ KTGETSRALS SSKQSSSSRD DNMFQIGKMR YVSVRDFKGK VLIDIREYWM DPEGEMKPGR KGISLNPEQW SQLKEQISDI DDAVRKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Activated RNA polymerase II transcriptional coactivator p15 (SUB1)