About Glycogen [starch] synthase, liver
Glycogen [starch] synthase, liver (GYS2) is a protein
from Homo sapiens identified by UniProt accession
P54840, 703 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Glycogen [starch] synthase, liver |
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| UniProt accession | P54840 |
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| Gene | GYS2 |
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| Organism | Homo sapiens |
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| Length | 703 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (149)
Diseases linked to this target (Open Targets).
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.79
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.76
- disorder of glycogen metabolism · score 0.63
- bilirubin measurement · score 0.37
- hemoglobin measurement · score 0.36
- mean platelet volume · score 0.34
- platelet count · score 0.33
- hematocrit · score 0.33
- C-reactive protein measurement · score 0.32
- serum gamma-glutamyl transferase measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54840-F1 | alphafold | PREDICTED | 86.70 | — |
Amino-acid sequence (703 residues)
MLRGRSLSVT SLGGLPQWEV EELPVEELLL FEVAWEVTNK VGGIYTVIQT KAKTTADEWG ENYFLIGPYF EHNMKTQVEQ CEPVNDAVRR AVDAMNKHGC QVHFGRWLIE GSPYVVLFDI GYSAWNLDRW KGDLWEACSV GIPYHDREAN DMLIFGSLTA WFLKEVTDHA DGKYVVAQFH EWQAGIGLIL SRARKLPIAT IFTTHATLLG RYLCAANIDF YNHLDKFNID KEAGERQIYH RYCMERASVH CAHVFTTVSE ITAIEAEHML KRKPDVVTPN GLNVKKFSAV HEFQNLHAMY KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN FLLRMHKSDI TVMVFFIMPA KTNNFNVETL KGQAVRKQLW DVAHSVKEKF GKKLYDALLR GEIPDLNDIL DRDDLTIMKR AIFSTQRQSL PPVTTHNMID DSTDPILSTI RRIGLFNNRT DRVKVILHPE FLSSTSPLLP MDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFMQE HVADPTAYGI YIVDRRFRSP DDSCNQLTKF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY LGRYYQHARH LTLSRAFPDK FHVELTSPPT TEGFKYPRPS SVPPSPSGSQ ASSPQSSDVE DEVEDERYDE EEEAERDRLN IKSPFSLSHV PHGKKKLHGE YKN
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