About Bax inhibitor 1
Bax inhibitor 1 (TMBIM6) is a protein
from Homo sapiens identified by UniProt accession
P55061, 237 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Bax inhibitor 1 |
|---|
| UniProt accession | P55061 |
|---|
| Gene | TMBIM6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 237 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.27
- intelligence · score 0.23
- vital capacity · score 0.21
- forced expiratory volume · score 0.20
- smoking behaviour measurement · score 0.19
- systolic blood pressure · score 0.13
- cancer · score 0.09
- hepatocellular carcinoma · score 0.08
- pulse pressure measurement · score 0.08
- attention deficit hyperactivity disorder · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55061-F1 | alphafold | PREDICTED | 91.86 | — |
Amino-acid sequence (237 residues)
MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV THFIQAGLLS ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALEFCIAVN PSILPTAFMG TAMIFTCFTL SALYARRRSY LFLGGILMSA LSLLLLSSLG NVFFGSIWLF QANLYVGLVV MCGFVLFDTQ LIIEKAEHGD QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK
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