IgG receptor FcRn large subunit p51 (FCGRT)

About IgG receptor FcRn large subunit p51

IgG receptor FcRn large subunit p51 (FCGRT) is a protein from Homo sapiens identified by UniProt accession P55899, 365 residues long. MolForge cross-references it against 0 known binders and 248 disease associations.

Target properties

Protein name	IgG receptor FcRn large subunit p51
UniProt accession	P55899
Gene	FCGRT
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (248)

Diseases linked to this target (Open Targets).

serum albumin measurement · score 0.68
total blood protein measurement · score 0.68
calcium measurement · score 0.59
Myasthenia gravis · score 0.57
hemoglobin measurement · score 0.43
erythrocyte count · score 0.40
hematocrit · score 0.39
autoimmune thrombocytopenic purpura · score 0.39
immune system disease · score 0.37
eye disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55899-F1	alphafold	PREDICTED	84.99	—

Amino-acid sequence (365 residues)

MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV IPATA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards