Nipocalimab
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Also known as: imaavy, M281, nipocalimab-aahu
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Nipocalimab is a drug catalogued in DrugCentral. It was first approved by the FDA in 2025. DrugCentral lists 1 molecular target, including FCGRT. Recorded indications include Myasthenia gravis.
- Molecular targets: FCGRT (1 listed in DrugCentral).
- Indications: Myasthenia gravis.
- ATC code: L04AL03 (Neonatal fragment crystallizable receptor (FcRn) inhibitors).
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Myasthenia gravis
Mechanism & targets
Molecular targets (1)
| Target | Gene | Action | Activity |
|---|---|---|---|
| IgG receptor FcRn large subunit p51 | FCGRT | other | Kd 9.68 |
Regulatory approvals (3)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 2025-11-28 | EMA | — | Janssen Cilag International NV | Yes |
| 2025-04-29 | FDA | — | Johnson & Johnson | |
| 2025-04-29 | PMDA | — | Janssen Pharmaceutical K.K. |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
L04AL03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSUPPRESSANTS › IMMUNOSUPPRESSANTS › Neonatal fragment crystallizable receptor (FcRn) inhibitors |
Chemical structure
| Molecular formula | — |
|---|---|
| Molecular weight | — |
| CAS number | — |
| InChIKey | — |
| PubChem CID | — |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Nipocalimab used for?
DrugCentral lists the following indications for Nipocalimab: Myasthenia gravis.
How does Nipocalimab work?
Its molecular targets in DrugCentral include FCGRT.
When was Nipocalimab first approved?
Nipocalimab was first approved by the FDA in 2025.
Browse: all drugs starting with N · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 5769 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL4594310 — compound record and bioactivity
- DrugBank DB16257 — drug record
- FDA UNII 87M90CV8NC — substance identity
- DailyMed: FDA labels for Nipocalimab — current prescribing information (label search)
- UniProt P55899 (FCGRT) — target protein
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