About Transmembrane protein 50B
Transmembrane protein 50B (TMEM50B) is a protein
from Homo sapiens identified by UniProt accession
P56557, 158 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Transmembrane protein 50B |
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| UniProt accession | P56557 |
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| Gene | TMEM50B |
|---|
| Organism | Homo sapiens |
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| Length | 158 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- serum albumin measurement · score 0.24
- serum gamma-glutamyl transferase measurement · score 0.18
- neurofibrillary tangles measurement · score 0.13
- rheumatoid arthritis · score 0.06
- body height · score 0.04
- corneal endothelial dystrophy · score 0.04
- Fuchs endothelial corneal dystrophy · score 0.04
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
- Megalocornea · score 0.04
- megalocornea · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56557-F1 | alphafold | PREDICTED | 83.31 | — |
Amino-acid sequence (158 residues)
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT
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